منابع مشابه
Fidelity in protein synthesis
predicts that unresolvable sexual arms races may be infrequent, and that it is more usual for one sex or the other to gain an evolutionary advantage, halting antagonistic co-evolution, even though the underlying conflict may not be resolved, or that a balance in 'arms levels' results. Exceptions may be common at the molecular level — for example, involving seminal proteins and receptors — where...
متن کاملFidelity at the Molecular Level: Lessons from Protein Synthesis
The faithful and rapid translation of genetic information into peptide sequences is an indispensable property of the ribosome. The mechanistic understanding of strategies used by the ribosome to achieve both speed and fidelity during translation results from nearly a half century of biochemical and structural studies. Emerging from these studies is the common theme that the ribosome uses local ...
متن کاملReduced Protein Synthesis Fidelity Inhibits Flagellar Biosynthesis and Motility
Accurate translation of the genetic information from DNA to protein is maintained by multiple quality control steps from bacteria to mammals. Genetic and environmental alterations have been shown to compromise translational quality control and reduce fidelity during protein synthesis. The physiological impact of increased translational errors is not fully understood. While generally considered ...
متن کاملThe role of initiator tRNAimet in fidelity of initiation of protein synthesis.
The proper arrangement of amino acids in a protein determines its proper function, which is vital for the cellular metabolism. This indicates that the process of peptide bond formation requires high fidelity. One of the most important processes for this fidelity is kinetic proofreading. As biochemical experiments suggest that kinetic proofreading plays a major role in ensuring the fidelity of p...
متن کاملHigh fidelity TNA synthesis by Therminator polymerase
Therminator DNA polymerase is an efficient DNA-dependent TNA polymerase capable of polymerizing TNA oligomers of at least 80 nt in length. In order for Therminator to be useful for the in vitro selection of functional TNA sequences, its TNA synthesis fidelity must be high enough to preserve successful sequences. We used sequencing to examine the fidelity of Therminator-catalyzed TNA synthesis a...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2005
ISSN: 0960-9822
DOI: 10.1016/j.cub.2005.07.018